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KMID : 0614019940100010162
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Journal of Pharmaceutical Sciences (C.N.U.)
1994 Volume.10 No. 1 p.162 ~ p.166
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Antitumor effect of 218Bismuth-conjugated anti-IL-2R monoclonal antibody(2E4) on a IL-2 recepter positive tumor EL4J3.4
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S. H. Kim
R. W. Kozak/K. S. Chung/B. Z. Ahn
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Abstract
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The antitumor effects of the 2E4 and anti-Tac, monoclonal antibodies directed to IL-2 receptor (IL-2R), conjugated with α-particle emitting radionuclide bismuth-212., were compared. The ^212Bi-2E4 demonstrated specific cytotoxicity to EL4J3.4, a IL-2R^+ cell line, than to EL4J, a IL-2R^- cell line in thymidine incorporation assay. ^212Bi-2E4 exerted the maximal antitumor effect in that % T/C in C57BL/6 mice implanted with EL4J3.4 ascitic tumor was 331% at the concentration of 50μCi, while that of ^212Bi-anti-Tac was 258% at 100μCi.
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KEYWORD
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